Clara Lago debuted in the film Miserable Life (2000), although mainly acting in television series, most notably Compañeros and Hospital Central. In 2002, starring Carol in Carol's Journey, directed by Imanol Uribe, for who she was nominated for the Goya Award for Best Young Actress. She played with Belén Rueda and Eduardo Noriega in the film For the Good of Others (2010), directed by Oskar Santos.